【摘 要】
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We prospectively assessed the effect of oral methadone on the corrected QT interval(QTc) among 160 patients free of structural heart disease and measured serum
【机 构】
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Dr. VA Connecticut Hlthcare. Coop. S. Building 36/116A-4 950 Campbell Avenue,West Haven CT 06516 Un
【出 处】
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世界核心医学期刊文摘(心脏病学分册)
论文部分内容阅读
We prospectively assessed the effect of oral methadone on the corrected QT interval(QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean±SD QTc increased by 12.4±23 ms(p< 0.001) at 6 months, by 10.7±30 ms(p< 0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough(r=0.37, p=0.008) and peak(r=0.32, p=0.03)serum methadone concentrations.
We prospectively assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean ± SD QTc increased by 12.4 ± 23 ms (p <0.001) at 6 months by 10.7 ± 30 ms (p <0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) 0.32, p = 0.03) serum methadone concentrations.
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