国内有关父子、母子及兄妹同患鼻咽癌的报道,但母子及叔侄一家四口二代同患鼻咽癌未见报道,现报道如下:1病例报告患者甲,男,37岁,于1990年12月开始出现鼻塞、鼻衄并伴有双颈部淋巴结肿大。CT检查诊断为鼻咽癌,病理证实:低分化鳞癌。经常规放射治疗和化疗后,生存20个月,因肝转移大出血而死亡。患者乙,男,40岁,(患者甲的大叔)于1978年3月开始发现晨起吸入性血痰,当时未立即就诊,2个月后症状加重并常伴有耳鸣,经耳鼻喉科检查,发现鼻咽腔后壁和双侧壁有一块状新生物,经病理检查证实为低分化鳞癌,由于家庭困难,放弃治疗,6个月后死亡。患者丙,女,54岁。(患者甲的母亲)于1984年1月开始出现鼻塞伴左颈部淋巴结进行性肿大,经耳鼻喉科检查,发现鼻咽顶后壁有菜花样肿物,经病理检查证实为低分化鳞癌。经常规放射治疗后生存14个月,因全身多发骨转移而死亡。患者丁,男,41岁,(患者甲的二叔) Domestic and relatives, mother and son and brother and sister with NPC reported, but the mother and son and a nephew of a family of four with the second generation of nasopharyngeal carcinoma has not been reported, are reported as follows: A case report patients A, male, 37 years old, at Beginning in December 1990 nasal obstruction, epistaxis and accompanied by double-neck lymph nodes. CT examination diagnosed as nasopharyngeal carcinoma, pathology confirmed: poorly differentiated squamous cell carcinoma. After conventional radiotherapy and chemotherapy, survive 20 months, due to liver metastasis and death of bleeding. Patient B, male, 40 years old, (patient A’s uncle) began to find inhaled bloody sputum in early March 1978 and was not treated immediately. After 2 months, the symptoms were aggravated and often accompanied by tinnitus. Found a piece of nasopharynx posterior wall and double wall of a new biological, pathologically confirmed as poorly differentiated squamous cell carcinoma, due to family difficulties, to give up treatment, died after 6 months. Patient C, female, 54 years old. (Patient A mother) began to appear in January 1984 nasal congestion with left cervical lymph node enlargement, the ENT examination found that the nasopharyngeal posterior wall of cauliflower tumor confirmed by the pathological examination of poorly differentiated scales cancer. After conventional radiotherapy survived 14 months, died of multiple bone metastases. Patient Ding, male, 41 years old, (patient A’s uncle)