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目的:观察帕米膦酸二钠与89Sr联合应用对激素非依赖型前列腺癌(PCa)伴骨转移的治疗效果。方法:将我院收治的29例激素非依赖型PCa伴骨转移患者随机分成A、B两组,A组采用帕米膦酸二钠90mg溶于5%葡萄糖500ml,缓慢滴注4周1次,共2次;B组静脉注射89SrCl21.48mBq/kg,1周后与A组治疗方法相同。采用疼痛视觉模拟法(VAS)评定患者主观骨痛,生活质量(QOL)评分来判定疗效。结果:在疼痛评分方面B组治疗后评分显著低于A组,生活质量评分有效率的差异无统计学意义。结论:帕米膦酸二钠联合89 Sr治疗激素非依赖型PCa伴骨转移在疼痛缓解有效率上高于单独使用帕米膦酸二钠,同时表明帕米膦酸二钠与89Sr具有协同作用,其在不良反应方面无明显增加。
Objective: To observe the therapeutic effect of combination of pamidronate and 89Sr on hormone-independent prostate cancer (PCa) with bone metastasis. Methods: Totally 29 cases of hormone-independent PCa with bone metastasis in our hospital were randomly divided into A and B groups. In group A, Pamidronate disodium 90mg was dissolved in 500ml of 5% glucose and slowly instilled once every 4 weeks , A total of 2 times; B group intravenous 89SrCl21.48mBq / kg, 1 week after treatment with the same method. Pain visual analogue (VAS) was used to assess patients’ subjective bone pain and quality of life (QOL) scores to determine efficacy. Results: In the pain score, the score of B group after treatment was significantly lower than that of A group, and there was no significant difference in the effective rate of quality of life between the two groups. CONCLUSION: Pamidronate disodium combined with 89 Sr is superior to pamidronate disodium alone in the efficacy of pain-free response to steroid-independent PCa with bone metastases. It also shows synergistic effect of pamidronate disodium and 89Sr , Its no significant increase in adverse reactions.