目的　观察顽固性咽喉部症状与胃食管酸反流的相关性 ,探讨患者症状发生的机制。并为顽固性咽喉部症状的患者提供新的治疗思路。方法　 1 病例选择 :试验组 :具有 6个月以上的咽喉部不适症状 ,如咽异物感 ,声音嘶哑 ,慢性干咳 ,呛咳等。经耳鼻喉科反复诊治及喉镜检查 ,未发现明 Objective To observe the correlation between intractable laryngeal symptoms and gastroesophageal reflux, and to explore the mechanism of the patients’ symptoms. And for the treatment of refractory throat symptoms in patients with new treatment ideas. Method 1 case selection: test group: with more than 6 months of throat discomfort symptoms, such as pharyngeal foreign body sensation, hoarseness, chronic dry cough, cough and so on. Otolaryngology repeated diagnosis and treatment of laryngoscopy, did not find out