Na+ / H+ 交换体是存在于真核细胞的一种膜蛋白 ,调节细胞内 p H、Na+ 浓度 (p Hi、 [Na+ ]i) ,在血管平滑肌增生性疾病如高血压、血管成形术后等情况下活性增高 ,通过使细胞内碱化及细胞内 Na+浓度升高 ,起促进细胞增殖、减少细胞凋亡作用 ,从而促进血管平滑肌细胞增殖 ;多种血管活性因子通过激活 Na+ / H+交换体引起血管平滑肌细胞增殖 ,故推测 Na+ / H+交换体抑制剂在治疗血管平滑肌细胞增生性疾病中有广泛应用前景 The Na + / H + exchanger is a membrane protein present in eukaryotic cells that regulates intracellular pH, Na + concentrations (p Hi, [Na +] i), in vascular smooth muscle proliferative diseases such as hypertension, angioplasty, etc. Case activity increased by intracellular alkalinization and intracellular Na + concentration, can promote cell proliferation and reduce apoptosis, thereby promoting vascular smooth muscle cell proliferation; a variety of vasoactive factors through the activation of Na + / H + exchange caused Vascular smooth muscle cell proliferation, it is speculated that Na + / H + exchanger inhibitors in the treatment of vascular smooth muscle cell proliferative diseases have a wide range of applications