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2月龄纯种雄性Wister大鼠,注射链脲佐菌素建立糖尿病大鼠模型后,随机分为糖尿病对照组和糖尿病耐力训练组;正常大鼠随机分为对照组和耐力训练组。训练组大鼠晚上在水池中进行游泳训练,每次60min,每周6次,共6周。最后一次训练结束后次日取组织测试,结果发现:耐力训练能使正常大鼠的血清NOS、腓肠肌NO活性显著提高;糖尿病使大鼠的血清NOS和NO、腓肠肌NOS和NO代偿性释放非常显著增多;耐力训练使糖尿病大鼠血清NO浓度增加,降低腓肠肌NOS和NO的水平,改善了糖尿病的代谢紊乱状态。
Two-month-old male Wistar rats were randomly divided into control group and endurance training group. Diabetic rats were randomly divided into diabetic control group and diabetic endurance training group. Training group rats swimming training in the pool at night, each 60min, 6 times a week for a total of 6 weeks. Tissue test was taken on the next day after the last training. The results showed that endurance training can significantly improve NO activity of serum NOS and gastrocnemius in normal rats; Diabetes can make the compensatory release of NOS and NO, gastrocnemius NOS and NO in rats significantly Significantly increased. Endurance training increased the concentration of NO in serum of diabetic rats, decreased the levels of nitric oxide and nitric oxide in gastrocnemius, and ameliorated the metabolic disturbance of diabetes.