目的 :探讨抗癫痫药苯巴比妥对癫痫患儿甲状腺功能的影响。方法 :对 35例癫痫患儿用苯巴比妥治疗 ,治疗前后血清 T3、T4、TSH进行测定 ,并与正常对照组比较。结果 :用药前 T3、T4与正常对照组比较无明显变化 ;用药后T3、T4显著降低 (P>0 .0 5 ,P<0 .0 1 ) ;用药前后 TSH无明显改变。结论 :癫痫患儿用苯巴比妥治疗后血清 T3、T4的改变主要是抗癫痫药苯巴比妥引起的。 Objective: To investigate the effect of antiepileptic phenobarbital on thyroid function in children with epilepsy. Methods: Thirty-five children with epilepsy were treated with phenobarbital, and the levels of serum T3, T4 and TSH were measured before and after treatment, and compared with the normal control group. Results: There was no significant difference between T3 and T4 before treatment and T3, T4 after treatment (P> 0.05, P <0.01). There was no significant change of TSH before and after treatment. Conclusion: The changes of serum T3 and T4 in children with epilepsy after treatment with phenobarbital are mainly caused by antiepileptic drug phenobarbital.