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国内调查发现,目前耳聋患儿半数以上由庆大霉素耳中毒所致,曾使用过庆大霉素的许多小儿均遗留有不同程度的听力下降。虽广大医务人员及病儿家属对此密切关注,但仍有不少医务人员对这种严重性未能引起足够的重视。耳中毒的机理庆大霉素是1963年发现的一种广谱抗生素,含去氧链霉胺,与链霉素、卡那霉素及新霉素同属氨基甙类抗生素。动物实验及临床观察证明其对内耳及听觉中枢通路均有毒性作用。引起感觉神经性聋和眩晕。短期、小剂量应用,其毒性可逐渐消失,
Domestic survey found that at present more than half of children with deafness caused by gentamicin ototoxicity, many children have been used gentamicin left behind with varying degrees of hearing loss. Although the majority of medical staff and sick children’s families pay close attention to this, many medical personnel still fail to pay sufficient attention to this seriousness. The mechanism of ototoxicity Gentamicin is a broad-spectrum antibiotics found in 1963, containing deoxy streptomycin, and streptomycin, kanamycin and neomycin belong to the same aminoglycoside antibiotics. Animal experiments and clinical observations prove that it has toxic effects on the inner ear and auditory central pathway. Causes sensory deafness and dizziness. Short-term, low-dose applications, its toxicity may gradually disappear,