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目的探讨B型利钠多肽(BNP)与慢性心力衰竭(CHF)的关系。方法53例CHF患者按病因分为冠状动脉粥样硬化性心脏病(CHD)组31例,特异性心肌病组22例,所有患者进行血浆N末端B型利纳多肽原(NT-proBNP)测定,并接受Swan-Ganz球囊漂浮导管检查,记录心腔压力并测得心排量(CO)和心脏指数(CI),评价不同病因患者之间NT-proBNP水平及与心功能参数之间的关系。结果NT-proBNP与CI之间存在较好的相关性,相关系数r=0.32;CHD与特异性心肌病导致的CHF患者血浆NT-proBNP水平分别是(38.74±34.672)ng×10-3/ml和(363.573±179.89)ng×10-3/ml,差异有显著性意义(P=0.01131);两组CI分别是(2.13±0.342)L/min.m2和(1.902±0.314)L/min.m2,差异无显著性意义(P=0.0754)。结论NT-proBNP浓度检测为临床方便、快捷地区分CHF病因提供了新的手段。
Objective To investigate the relationship between type-B natriuretic peptide (BNP) and chronic heart failure (CHF). Methods Totally 53 patients with CHF were divided into etiopathogenisis of coronary heart disease (CHD) group (n = 31) and specific cardiomyopathy group (n = 22). All patients were enrolled in this study. Plasma N - terminal NT - proBNP , And underwent balloon catheterization with Swan-Ganz balloon catheterization. Cardiac pressure was recorded and cardiac output (CO) and cardiac index (CI) were recorded. NT-proBNP levels and cardiac function parameters between patients with different etiologies relationship. Results There was a good correlation between NT-proBNP and CI, the correlation coefficient was 0.32. The plasma levels of NT-proBNP in CHF patients with CHD and idiopathic cardiomyopathy were (38.74 ± 34.672) ng × 10-3 / ml And (363.573 ± 179.89) ng × 10-3 / ml, respectively (P = 0.01131). The CI of the two groups were (2.13 ± 0.342) L / min.m2 and (1.902 ± 0.314) L / min, respectively. m2, the difference was not significant (P = 0.0754). Conclusion The detection of NT-proBNP concentration provides a new means to distinguish the cause of CHF quickly and conveniently.