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比较了抗癌结构类似物吗丙嗪和雷佐生对红细胞膜钙调蛋白 (CaM)活性的影响 .观察兔红细胞膜Ca2 +,Mg2 + ATP酶 (CaM的靶酶 )活性反映膜CaM激活ATP酶的活性 .结果显示吗丙嗪 ( 0 .1～ 1mmol·L- 1)浓度依赖性抑制CaM激活ATP酶活性 (下降11%～ 32 % ) .雷佐生在高浓度 ( 0 .5mmol·L- 1)仍未显示抑制CaM激活ATP酶活性的作用 .吗丙嗪在低浓度 ( 0 .0 2～ 0 .1mmol·L- 1)能增加N 乙酰神经氨酸( 0 .2mmol·L- 1)抑制CaM激活ATP酶活性的作用 .结果表明吗丙嗪对CaM活性的抑制作用强于雷佐生 ,因而可能在CaM介导的抑瘤途径的作用较雷佐生强 ,且其作用可能与神经氨酸 (唾液酸 )有关
The effects of anti-cancer analogs mpromazine and razosin on the activity of erythrocyte membrane calmodulin (CaM) were compared.The activity of Ca2 + and Mg2 + ATPase (the target enzyme of CaM) (0.1-1.0 mmol·L-1) inhibited the activity of CaM-activated ATPase in a concentration-dependent manner (decreased by 11% -32% ) Has not yet been shown to inhibit CaM-activated ATPase activity.Morphophenine (0. 02 mmol·L-1) at a low concentration CaM activates the activity of ATPase.The results show that the inhibition of CaM activity of the methamphetamine is stronger than that of raszepor and thus may be more effective than the Razosuin in CaM-mediated anti-tumor pathways, and its effect may be related to neuraminic acid ( Sialic acid)