作者对12名原发性肾小球疾病接受环磷酰胺治疗的青年男性未婚患者进行随访,现将其对生殖能力的影响介绍如下。方法:静注环磷酰胺1.5～3.5mg/kg 体重,每日或隔日一次,见效后逐渐减量至停药。随访结果:本组用药量在24.2～61g,持续用药293～656天之间的5例中,4例婚后女方未孕,已结婚时间均在3年以上。女方均经医院检查身体健康,男方无生殖系疾病及其他慢性疾病史。7例用药 The authors followed up 12 unmarried young men who were treated with cyclophosphamide in patients with primary glomerular disease and now describe their effects on reproductive capacity as follows. Methods: Intravenous injection of cyclophosphamide 1.5 ~ 3.5mg / kg body weight, daily or every other day, after the effective tapering to withdrawal. Follow-up results: The group of medication in 24.2 ~ 61g, continuous medication 293 ~ 656 days in 5 cases, 4 cases of married women are not pregnant, have been married for more than 3 years. The woman was examined by the hospital for good health, the man no history of reproductive diseases and other chronic diseases. 7 cases of medication