论文部分内容阅读
细胞周期的调控涉及到众多细胞因子的参与,细胞周期相关转录因子E2F家族是其重要的调控环节之一。其中E2F-1既可以调控细胞周期G_1向S期的过渡,又可以诱导许多正常和肿瘤细胞的凋亡,兼有癌基因和抑癌基因的特性。尽管E2F-1通过pRb及相关蛋白等多种细胞周期依赖蛋白及激酶的相互作用调控细胞周期的通路比较明确,但是其诱导细胞凋亡的复杂机制还不甚明确,基于近期的研究对E2F-1诱导细胞凋亡的通路做以下综述。1 E2F家族成员1986年Kovesdi等研究腺病毒感染细胞的核抽提物与
The regulation of the cell cycle involves many cytokines, and the E2F family of cell cycle related transcription factors is one of its important regulatory elements. Among them, E2F-1 can regulate the transition from cell cycle G 1 to S phase and induce apoptosis of many normal and tumor cells with the features of both oncogenes and tumor suppressor genes. Although the mechanism of E2F-1 regulating the cell cycle through the interaction of various cell cycle-dependent proteins and kinases such as pRb and related proteins is relatively clear, the complicated mechanism of apoptosis induction by E2F-1 is not clear. Based on recent studies, E2F- 1-induced apoptosis pathway to do the following review. 1 E2F family members in 1986 Kovesdi et al. Adenovirus-infected cells nuclear extracts and research