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目的:评价替硝唑棒对牙周炎和冠周炎病原菌的抗菌作用。方法:(1)采用厌氧菌药物敏感试验的二倍琼脂稀释法测定替硝唑和甲硝唑对200株临床分离株的MIC50和MIC90。(2)采用厌氧菌培养方法测定51例牙周炎和冠周炎患者局部应用替硝唑和甲硝唑前后,牙周炎病原菌和冠周炎病原菌的变化。结果:替硝唑棒剂对牙龈卟啉单胞菌、中间普氏菌、梭杆菌和消化链球菌具有明显抗菌作用,其MIC50和MIC90分别为0.25、0.25、0.25、8 mg/L和0.5、0.5、1、8mg/L;其清除率为94.4％～100％,细菌数量均有明显减少。替硝唑对牙周炎和冠周炎病原菌的抗菌活性明显强于甲硝唑(P<0.05)。结论:局部应用替硝唑棒可明显抑制牙周炎和冠周炎的病原菌。
OBJECTIVE: To evaluate the antibacterial effect of tinidazole rod on pathogenic bacteria of periodontitis and periostitis. Methods: (1) The MIC50 and MIC90 of tinidazole and metronidazole to 200 clinical isolates were determined by double agar dilution method using anaerobic drug susceptibility test. (2) The anaerobic bacteria culture method was used to determine the changes of pathogenic bacteria and pericoronitis pathogens in 51 patients with periodontitis and pericoronitis before and after tinidazole and metronidazole application. Results: Tinidazole had obvious antibacterial activity against Porphyromonas gingivalis, Prevotella, Fusobacterium and Peptostreptococcus, and its MIC50 and MIC90 were 0.25, 0.25, 0.25, 8 mg / L and 0.5, respectively. 0.5,1,8 mg / L; the clearance rate was 94.4% ~ 100%, the number of bacteria were significantly reduced. The antibacterial activity of tinidazole to periodontitis and pericoronitis was significantly higher than that of metronidazole (P <0.05). CONCLUSION: Topical application of tinidazole rod can significantly inhibit pathogenic bacteria of periodontitis and pericoronitis.