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本文所提供的资料指出,人类根尖周病的骨质吸收是多因素的。活菌、细菌产物和改变了的宿主组织都能引起根尖周病的发生和发展。这种对来自根管内持久抗原刺激的反应可能为两种形式:抗体中介免疫和细胞中介免疫。抗原抗体复合物和IgE中介反应能引起根尖周组织的初期改变。迟发过敏反应(细胞中介免疫)很可能参与根尖周病的发生发展过程。虽然免疫反应对来自根管的抗原物质的局限和破坏是重要的,但常常导致根尖周组织的破坏。很可能根尖周病是免疫系统致力保护宿主免受根管内有害物质的袭击所造成的副产品而使根尖周组织遭受慢性破坏。根据上述资料,免疫系统对根尖周病作用的意义是很清楚的。然而尚需更多的研究来解答许多遗留问题。
The information provided in this article suggests that bone resorption in human apical disease is multifactorial. Viable bacteria, bacterial products and altered host tissue can cause the occurrence and development of periapical disease. This response to persistent antigenic stimulation from the root canal may take two forms: antibody mediated immunity and cell mediated immunity. Antigen-antibody complexes and IgE mediators can cause initial changes in periapical tissue. Delayed allergic reaction (cell mediated immune) is likely to be involved in the pathogenesis of periapical disease development. Although the immune response is important for the localization and destruction of antigenic material from the root canal, it often leads to destruction of periapical tissue. It is likely that periapical disease is a chronic disruption of the periapical tissue caused by the immune system ’s commitment to protect the host from the byproduct of attack by harmful substances in the root canal. According to the above information, the significance of the immune system on periapical disease is very clear. However, more research is still needed to answer many of the remaining issues.