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本文报道9个研究室同时用反相HPLC 法测定合成和市售的6种片剂和胶囊样品中舒宁的含量。测得平均回收率分别为97.2和99.0%,平均变异系数为1.85～2.86%。本法已被法定法采用。仪器用204型液相层析仪,配备二6000A 型泵;660型溶剂程序;440型UV 检测器(254nm);U6K型注射器;3380A 型积分仪;C_(18)硅烷键合相柱30cm×3.9mm(内径)和0.2μm Millipore EG 型滤器。试剂甲醇为紫外纯或相当等级。流动相甲醇-水-冰醋酸(60:40:1),流速1.0ml/分,改变甲醇浓度和
In this paper, nine laboratories were also tested by reverse-phase HPLC method for the content of Shuning in six kinds of tablets and capsules synthesized and commercially available. The average recoveries were 97.2 and 99.0%, respectively. The average coefficient of variation was 1.85 ~ 2.86%. This Law has been adopted by statutory law. Model 204 liquid chromatograph equipped with two 6000A pumps; 660 solvent program; 440 UV detector (254 nm); U6K syringe; Model 3380A integrator; C 18 silane-bonded phase column 30 cm × 3.9 mm (inner diameter) and 0.2 μm Millipore EG filters. Reagent methanol is pure or equivalent to UV grade. The mobile phase was methanol-water-glacial acetic acid (60: 40: 1) and the flow rate was 1.0 ml / min. The methanol concentration and