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目的研究P53、Bcl-2、P16和c－myc基因在卵巢上皮性肿瘤中的意义。方法采用免疫组织化学法（SABC法）对80例良性、26例交界性和116例恶性卵巢上皮性肿瘤P53、Bcl-2、P16和c-myc癌基因的表达情况进行检测。结果P53、Bcl-2、P16和c－myc表达率分别为36．48％、27．47％、83．33％和52．25％，P53、Bcl-2、c-myc表达随恶性程度增加而增高，良恶性之间表达差异有显著意义（P＜0．01），P16随恶性程度增高表达率降低，恶性和良队间表达差异有显著性（P＜0．01），恶性肿瘤中的P53、Bcl-2和c－myc随分期增加，表达增加。结论四种癌基因在卵巢上皮性肿瘤中高表达或表达失调，良恶性之间表达差异有显著意义，表明它们在卵巢上皮性肿瘤发生、发展中起重要作用。
Objective To study the significance of P53, Bcl-2, P16 and c-myc in ovarian epithelial tumor. Methods The expression of oncogene P53, Bcl-2, P16 and c-myc in 80 cases of benign, 26 cases of borderline and 116 cases of malignant epithelial ovarian tumors were detected by immunohistochemistry (SABC method). Results The expression rates of P53, Bcl-2, P16 and c-myc were 36.48%, 27.47%, 83.33% and 52.25% respectively. The expression of P53, Bcl-2 and c-myc were increased with the degree of malignancy (P <0.01). The expression of P16 decreased with the increase of the degree of malignancy, and there was significant difference between the malignant and the good team (P <0.01). In malignant tumors P53 , Bcl-2 and c-myc increased with staging, expression increased. Conclusion The four oncogenes are highly or downregulated in epithelial ovarian tumors, and the difference between them is significant, indicating that they play an important role in the development and progression of ovarian epithelial tumors.