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目的:探讨质子泵抑制剂埃索美拉唑预防肾移植术后胃肠道并发症的疗效及安全性。方法:将122例肾移植术患者,分为埃索美拉唑组(76例)和雷尼替丁组(46例),术后分别应用埃索美拉唑、雷尼替丁预防胃肠道并发症,观察2组术后胃肠道并发症及埃索美拉唑不良反应发生情况。结果:埃索美拉唑组术后第1,2,3,4周相同时间点同一胃肠道症状发生率低于雷尼替丁组(P<0.05);埃索美拉唑组胃肠道出血发生率低于雷尼替丁组(P<0.05);埃索美拉唑组患者耐受性良好,不良反应轻,雷尼替丁组患者1例出现皮疹,1例发生血清谷丙转氨酶升高。结论:埃索美拉唑能够降低肾移植术后胃肠道并发症的发生率并减少胃肠道出血,不良反应轻,是预防肾移植术后胃肠道并发症有效的质子泵抑制剂。
Objective: To investigate the efficacy and safety of proton pump inhibitor esomeprazole in preventing gastrointestinal complications after renal transplantation. Methods: 122 renal transplant recipients were divided into esomeprazole group (n = 76) and ranitidine group (n = 46). Postoperative esomeprazole and ranitidine were given to prevent gastrointestinal Road complications, gastrointestinal complications and esomeprazole adverse reactions were observed in two groups. Results: The incidence of the same gastrointestinal symptoms at the same time point was lower in the esomeprazole group than in the ranitidine group (P <0.05) The incidence of hemorrhage in the ranitidine group was lower than that in the ranitidine group (P <0.05). The patients in the esomeprazole group were well tolerated and had mild adverse reactions. One patient in the ranitidine group developed a rash and one patient developed serum alanine Elevated aminotransferases. Conclusion: Esomeprazole can reduce the incidence of gastrointestinal complications after renal transplantation and reduce gastrointestinal bleeding with mild adverse reactions. It is an effective proton pump inhibitor to prevent gastrointestinal complications after renal transplantation.