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吲达帕胺是一种新型噻嗪类磺胺利尿剂,是具有轻微利尿作用的血管扩张药,已广泛用于临床。本研究采用随机、对照、开放的方法比较观察吲达帕胺和波依定对老年收缩期高血压的降压效果与安全性。1资料与方法1.1一般资料70例均符合1999年WHO/ISH高血压治疗指南标准SBP>140/DBP<90mmHg。其中男53例,女17例;年龄60-82岁,平均71.2岁。随机分为吲达帕胺组和波依定组。本组病例排除标准:①继发性高血压;②近期(6月)内发生脑卒中、TIA、心肌梗死、心力衰竭;③严重肝肾功能不全;④痛风、高尿酸血症(男>416μmol/L,女性>357μmoL/L);⑤磺胺药过敏者。
Indapamide is a novel thiazide sulfadiazine diuretic that is a vasodilator with a slight diuretic effect and has been used clinically. In this study, randomized, controlled, open comparison of indomethacin and bepretrine on elderly antihypertensive effect and safety of systolic hypertension. 1 Materials and Methods 1.1 General Information 70 patients were in line with 1999 WHO / ISH guidelines for the treatment of hypertension SBP> 140 / DBP <90mmHg. Including 53 males and 17 females; aged 60-82 years, an average of 71.2 years. Randomly divided into indapamide group and wave Yi Ding group. The patients excluded criteria: ① secondary hypertension; ② recent (June) occurred stroke, TIA, myocardial infarction, heart failure; ③ severe liver and kidney dysfunction; ④ gout, hyperuricemia (male> 416μmol / L, female> 357μmoL / L); ⑤ sulfa allergy.