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目的探讨EB病毒(EBV)感染儿童外周血病毒量与临床特征的相关性。方法选择2015年1~12月入住福建省妇幼保健本院且EBV-DNA检测阳性的患儿257例,依EBV-DNA含量分为低、高拷贝量组,比较2组患儿的症状体征、实验室检查及合并感染情况。结果与低拷贝量组比较,高拷贝量组热程较长,常见症状(肝脾肿大、淋巴结肿大、眼睑水肿)较重;外周血白细胞计数、淋巴细胞比例、丙氨酸转氨酶、天冬氨酸转氨酶水平更高。两种临床表现(发热及皮疹)、C-反应蛋白(CRP)及肌酸激酶同功酶两组间差异无统计学意义。高拷贝量组与低拷贝量组间合并其他病原体感染发生率,高拷贝量组(38.7%)高于低拷贝量组(24.6%),但差异无统计学意义。结论EBV外周血病毒拷贝量与临床特征有一定相关性,可用于EBV感染病情评估。
Objective To investigate the correlation between peripheral blood viral load and clinical features in children with Epstein-Barr virus (EBV) infection. Methods A total of 257 children with MVD in our hospital from January to December 2015 who were positive for EBV-DNA in Fujian Province were enrolled in this study. The EBV-DNA content was divided into low and high copy volume groups. Symptoms and signs were compared between the two groups. Laboratory tests and combined infection. Results Compared with the low-copy-dose group, the high-copy-dose group had a longer heat history, and the common symptoms (hepatosplenomegaly, lymphadenopathy and eyelid edema) were severe. The peripheral blood leucocyte count, lymphocyte ratio, alanine aminotransferase, Aspartate aminotransferase levels higher. There was no significant difference between the two clinical manifestations (fever and rash), C-reactive protein (CRP) and creatine kinase isoenzyme. The incidence of other pathogen infections with high copy number and low copy number groups was higher than that of high copy number (38.7%) and low copy number groups (24.6%), but the difference was not statistically significant. Conclusion The copy number of EBV peripheral blood virus has a certain correlation with clinical features and can be used for the evaluation of EBV infection.