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本实验观察了阿霉素(ADR)对大鼠抗氧化酶(超氧化物歧化酶、谷胱甘肽过氧化物酶)及心脏的毒性作用,以及补充锌或锌+铜后对阿霉素毒性作用的保护作用。将体重130～160g雌雄各半的Wistar大鼠按体重、性别随机分为四个组,甲组是锌+阿霉素组,乙组是锌+铜+阿霉素组,丙组是单纯阿霉素组,丁组是生理盐水对照组。结果表明:丙组动物红细胞超氧化物歧化酶(SOD)和全血谷胱甘肽过氧化物酶(GSH-Px)的活性显著降低,心脏亦有明显的损害和心功能不全;甲、乙二组动物的SOD、GSH-Px活性显著高于丙组,心脏的损害亦明显轻于丙组;丁组无以上改变。实验结果提示适量的锌或锌+铜对阿霉素的毒性作用有保护作用,锌+锌铜组的保护效果好于单纯锌组。
In this study, we observed the toxic effects of adriamycin (ADR) on antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and heart in rats, and the effects of adriamycin Protection of toxic effects. Wistar rats weighing 130-160 g were randomly divided into four groups according to body weight and sex. Group A was zinc + doxorubicin, group B was zinc + copper + doxorubicin, group C was simple Mice group, small group is saline control group. The results showed that: the activities of erythrocyte superoxide dismutase (SOD) and whole blood glutathione peroxidase (GSH-Px) in group C were significantly decreased, and the heart also had obvious damage and cardiac dysfunction; The activities of SOD and GSH-Px in the two groups were significantly higher than those in group C, and the damage in heart was also obviously lower than that in group C; The experimental results suggest that the appropriate amount of zinc or zinc + copper has a protective effect on the toxic effects of doxorubicin, and the protective effect of the zinc + zinc-copper group is better than that of the pure zinc group.