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肾移植受者移植后恶性肿瘤危险率达80％。在免疫功能受到抑制时,皮肤和粘膜易患恶性肿瘤。在肾移植受者的皮肤、粘膜恶性肿瘤中发现非常高的人乳头瘤病毒(HPV)感染,致癌病危亚型HPV16、18更常见于肾移植受者的女性生殖道。HPV是一种易侵犯皮肤和粘膜的肿瘤病毒,是皮肤、粘膜恶性肿瘤发生发展的重要因素。充分认识和积极干预将减少肾移植受者移植后的常见合并症-皮肤、粘膜恶性肿瘤的发病率和死亡率,有助于提高患者生活质量、延长寿命。
Renal transplant recipients have a 80% risk of malignancy after transplantation. Skin and mucous membranes are susceptible to malignancy when immune function is suppressed. Very high human papillomavirus (HPV) infection is found in the skin, mucosal malignancies of renal transplant recipients, and the oncogenic, crisis-subtype HPV16,18 is more common in the female reproductive tract of kidney transplant recipients. HPV is a kind of tumor virus that easily invades the skin and mucous membrane and is an important factor for the development of skin and mucosal malignant tumors. Fully understanding and active intervention will reduce the morbidity and mortality of common complications of transplanted kidney transplant recipients - skin and mucosal malignancies, and help to improve the quality of life of patients and prolong their life expectancy.