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为探讨前额叶皮层局限性损伤对大鼠学习、记忆功能及基底前脑胆硷能神经元的影响。用外科手术造成大鼠 1侧前额叶皮层局限性损伤后不同时间 ,用Y型迷宫检测学习、记忆功能 ,用组织化学技术检测基底前脑含乙酰胆硷酯酶 (AchE)活性神经元。结果为前额叶皮层损伤后 1周 ,动物学习、记忆功能有所障碍 ,损伤同侧的基底前脑胆硷能神经元有所减少 ,但均无统计学意义。损伤后 2、3、4周 ,动物学习、记忆障碍明显 ,损伤同侧基底前脑胆硷能神经元明显减少 (P <0 .0 5) ,且两者变化相平行。结论为单侧前额叶皮质局限性损伤不仅可引起动物学习、记忆功能障碍 ,且可引起同侧基底前脑胆硷能神经元丢失 ,两者发展且相平行 ,提示基底前脑胆硷能神经元逆行性变性在动物额叶皮层损伤引起的学习、记忆障碍中起作用。
To investigate the effects of localized prefrontal cortex injury on learning, memory and basal forebrain cholinergic neurons in rats. The rats were subjected to surgical operation to establish the prefrontal cortex of rat with local injury at different time points. The learning and memory function was detected by Y-maze, and the acetylcholinesterase (AchE) -reactive neurons in the basal forebrain were detected by histochemistry. The results showed that 1 week after prefrontal cortex injury, learning and memory impairment of the animals, damage to ipsilateral basal forebrain cholinergic neurons decreased, but no statistically significant. At 2, 3 and 4 weeks after injury, animal learning and memory impairment were obvious, and cholinergic neurons in injured ipsilateral basal forebrain were significantly reduced (P <0.05), and the changes were parallel. Conclusions: Local unilateral prefrontal cortex injury can not only cause animal learning, memory dysfunction, and can cause ipsilateral basal forebrain cholinergic neurons loss, both developed and parallel, suggesting basal forebrain cholinergic nerve Recessive metamorphosis plays a role in learning and memory impairment caused by frontal cortex injury in animals.