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作者报道了3例原发性肺结核,在应用抗痨药物治疗的过程中引起病情恶化和喘息发作。例1、2分别为7岁和15个月的儿童,均有肺中叶病变伴肺门淋巴结肿大。结核菌素试验阳性。例1自胃灌洗液中查见了结核杆菌。例1应用异烟肼、乙胺丁醇和链霉素3个月和例2应用异烟肼、利福平和链霉素2个月后均出现病情恶化、喘息发作。例1 FVC 和FEV_1明显降低。支气管镜(BS)和活检分别显示右中叶支气管内膜肉芽肿和右支气管主干肉芽肿伴坏死。例1应用皮质激素后缓解。
The authors reported three cases of primary pulmonary tuberculosis, which caused aggravation and wheezing during treatment with anti-tuberculosis drugs. Cases 1 and 2, respectively, 7-year-old and 15-month-old children had lung disease with hilar lymph node enlargement. Tuberculin test positive. Example 1 Mycobacterium tuberculosis was found in gastric lavage fluid. Example 1 Application isoniazid, ethambutol and streptomycin for 3 months and Example 2 The application of isoniazid, rifampin and streptomycin after 2 months were exacerbations, wheezing episodes. Example 1 FVC and FEV_1 significantly reduced. Bronchoscopy (BS) and biopsy showed right middle lobe endometrial granuloma and right bronchogenic granuloma with necrosis, respectively. Example 1 corticosteroids after remission.