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为了从血清结合珠蛋白（Ｈａｐｔｏｇｌｏｂｉｎ，Ｈｐ）的遗传多态现象探讨复发性口疮发生的遗传易感性，本研究对１０８例复发性口疮患者进行了Ｈｐ型别测定并分析基因频率，与正常对照组进行比较分析。结果发现正常人对照组血清Ｈｐ２－２表型频率为０．５３７、Ｈｐ２－１０．３７２、Ｈｐ１－１０．０８４。１０８例复发性口疮患者血清Ｈｐ２－２为０．４９０、Ｈｐ２－１０．４１７、Ｈｐ１－１０．０５５。患者组Ｈｐ２－１表型频率高于正常对照组，经ｘ２检验，差异有显著性（Ｐ＜０．０５）。结果表明带有Ｈｐ２－１表型的人群可能对复发性口疮有遗传易感性。提示对于带有血清Ｈｐ２－１表型的人群应加强保护措施，避免环境因素的影响，从而降低复发性口疮的发病率。
In order to explore the genetic susceptibility to recurrent aphthous ulcer from the genetic polymorphism of serum Haptoglobin (Hp), 108 Hp genotypes were determined in patients with recurrent aphthous ulcer and the frequency of gene was analyzed. Compared with the normal control group For comparative analysis. The results showed that the normal control group serum Hp2-2 phenotype frequency was 0.537, Hp2-10.372, Hp1-10.084.108 cases of recurrent aphthous patients serum Hp2-2 was 0.490, Hp2-10.417 , Hp1-10.055. The phenotype frequency of Hp2-1 in patients was higher than that in normal control group, and the difference was significant (P <0.05) by x2 test. The results show that people with Hp2-1 phenotype may have a genetic susceptibility to recurrent aphthous ulcers. Tip For people with a serum Hp2-1 phenotype should strengthen protective measures to avoid the impact of environmental factors, thereby reducing the incidence of recurrent aphthous.