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作者自1979～1985年对住院的28例病程在2月以上,无肠切除术史,并经生化、放射学与内镜检查均无异常发现的慢性腹泻患者作为研究对象.每一患者在每天固定摄入脂肪100g的条件下,连续3天测定24小时粪便内总脂肪与总胆汁酸量,其中16例患者并应用同位素标记法进行SchillingⅡ试验.总胆汁酸系采用酶学法测定3α-羟基-胆酸,总脂肪按Van de Kamer法测定经酯化与未被酯化的羟基油脂.除11例经6～67月(平均38月)随访病因仍不明外,其余17例最后明确为炎症性肠病、小肠憩室或胃酸缺乏所致肠道细菌过度生长、滥用泻药或因迷走神经切断手术后所致的渗透性腹泻.
The authors studied 28 hospitalized patients with chronic diarrhea over 2 months from 1979 to 1985 with no history of bowel resection and chronic diarrhea without abnormal findings in biochemistry, radiology and endoscopy, Total fat and total bile acid in the feces were determined 24 hours after the fixed fat intake of 100g, Schilling Ⅱ test was carried out in 16 patients by isotope labeling method.The total bile acid was measured enzymatically by 3α-hydroxy - Cholic acid and total fat were determined by the Van de Kamer method of esterified and non-esterified hydroxy fat.In addition to 11 cases from June to June (average 38 months) follow-up etiology is still unknown, and the remaining 17 cases finally clear inflammation Enteropathy, intestinal bacterial diverticula or gastric acid deficiency caused by overgrowth of intestinal bacteria, abuse of laxatives or vagotomy caused by vaginal transmural surgery after diarrhea.