通过硅胶促进的L-氨基酸酯与取代氮丙啶的开环反应合成了一系列手性氨基酸衍生的二胺和三胺化合物,上述开环反应可被超声波加速.所得化合物的结构经1H NMR,13C NMR,IR,元素分析等手段表征.S-2-(二(2-(4-甲基苯磺酰胺乙基)胺基-3-甲基丁酸甲酯(4c)的结构经X射线单晶衍射进一步确定.L-脯氨酸甲酯(1d)与2-异丙基-N-对甲苯磺酰氮丙啶(5)发生1-3开环反应选择性形成化合物6b. A series of chiral amino acid-derived diamine and triamine compounds were synthesized by ring-opening reaction of L-amino acid esters and substituted aziridines. The above ring-opening reaction can be accelerated by ultrasound. The structures of the obtained compounds were confirmed by 1H NMR, 13C NMR, IR, elemental analysis, etc. The structure of S-2- (methyl 2- (4-methylbenzenesulfonamidoethyl) amino-3-methylbutanoate (4c) Single-crystal diffraction was further confirmed by the ring-opening reaction of L-proline methyl ester (1d) with 2-isopropyl-N-p-toluenesulfonyl aziridine (5) to form compound 6b.