目的观察二氧化钛对接触工人血液学及生化指标的影响,为职业健康监护和职业病预防提供客观依据。方法收集某企业集团生产工人2015年的职业健康检查和职业病危害因素检测资料,以其中钛白粉生产车间(工段)工人185名为接触组,其他不接触二氧化钛的硫酸生产车间(工段)工人87名为对照组,将两组异常结果进行统计分析。结果接触组的血液学及血液生化指标异常率分别为55.1%和66.1%,均高于对照组的46.0%和64.4%,但差异无统计学意义(P>0.05);接触组的血液学异常指标主要为红细胞分布宽度变异系数(RDW-CV)、红细胞分布宽度、红细胞平均体积偏高、平均血红蛋白浓度异常(偏高或偏低)和平均血小板压积偏低;血液生化指标主要为丙氨酸转氨酶(ALT)活力、天冬氨酸转氨酶/丙氨酸转氨酶/(AST/ALT)活力比值、谷氨酰转肽酶活力、碱性磷酸酶活力、直接胆红素、间接胆红素和总胆红素含量异常。结论二氧化钛对接触工人的血液学及生化指标存在不良影响,用人单位应定期对二氧化钛职业接触者进行职业健康检查,检查项目应包含血细胞形态、胆红素代谢和肝功酶类等。 Objective To observe the influence of titanium dioxide on the hematology and biochemical indexes of exposed workers and provide objective evidences for occupational health monitoring and prevention of occupational diseases. Methods The data of occupational health checkups and occupational hazards in 2015 were collected from a group of production workers in 2015. Among them, 185 were workers in the titanium dioxide production workshop (section) and 87 were workers in other sulfuric acid production workshops (non-titanium dioxide) As the control group, two groups of abnormal results for statistical analysis. Results The hematological and blood biochemical abnormalities in the exposure group were 55.1% and 66.1%, respectively, which were higher than those in the control group (46.0% and 64.4%, respectively), but the difference was not statistically significant (P> 0.05) The indexes were mainly the RDW-CV, the width of erythrocytes, the average volume of erythrocytes, the average abnormal hemoglobin concentration (high or low) and mean platelet pressure, and the main blood biochemical indexes were ammonia ALT activity, aspartate aminotransferase / alanine aminotransferase / (AST / ALT) activity ratio, glutamyl transpeptidase activity, alkaline phosphatase activity, direct bilirubin, indirect bilirubin and Total bilirubin content is abnormal. Conclusion Titanium dioxide has adverse effects on the hematology and biochemical indexes of exposed workers. Employers should conduct regular occupational health examination of occupational exposure to titanium dioxide. The examination items should include blood cell morphology, bilirubin metabolism and hepatic enzymes.