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可乐定(Clonidine)为中枢性降压药。最近作者用于治疗特发性溃疡性结肠炎,疗效显著。 45名病人(男20名,女25名)年龄17—51岁,患慢性和严重溃疡性结肠炎。按随机双盲试验法将病人分为强的松组(A组)、柳氮磺胺吡啶组(B组)、可乐定组(C组)。每组15名病人,研究分五个周期进行。各组在第二、四周期服用安慰剂,一、三、五周期服用活性药物:强的松20mg/次,tid(每周期的最后12天逐渐减量2.5mg/天);柳氮磺胺吡啶1.5g/次,tid;可乐宁0.3mg,tid。结果:强的松组显效10人,弱效2人,无效3
Clonidine is a central antihypertensive drug. Recent author for the treatment of idiopathic ulcerative colitis, a significant effect. Forty-five patients (20 males and 25 females) aged 17-51 years with chronic and severe ulcerative colitis. Patients were divided into prednisone group (group A), sulfasalazine group (group B) and clonidine group (group C) according to a randomized double-blind trial. Each group of 15 patients, the study carried out in five cycles. Each group took placebo in the second and fourth cycles, taking the active drug in one, three or five cycles: prednisone 20mg / time, tid (2.5mg / day tapering during the last 12 days of the cycle); sulfasalazine 1.5g / time, tid; Clonidine 0.3mg, tid. Results: Prednisone group markedly effective 10 people, weak effect 2, invalid 3