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目的：观察帕金森氏病患者脑立体定向术前、后脑脊液中神经递质水平的变化，这种变化的作用机理如何。方法：对１５例帕金森氏病患者丘脑腹外侧核毁损术前及术后一周脑脊液中单胺类递质水平检测及手术疗效观察。结果：患者术后脑脊液中多巴胺水平与术前无显著差异，而５－羟色胺、去甲肾上腺素、５－羟吲哚乙酸显著减少，术后毁损区对侧上下肢体震颤、肌强直消失，但运动不能症状未能改善。结论：帕金森氏病术后中枢多种神经递质发生改变并在低水平下暂时获得平衡。从中枢神经递质生化变化，脑立体定向术不能彻底治愈帕金森氏病
OBJECTIVE: To observe the changes of neurotransmitters in cerebrospinal fluid of patients with Parkinson’s disease before and after stereotactic stereotactic surgery. What is the mechanism of this change? Methods: The levels of monoamine neurotransmitters in cerebrospinal fluid (CSF) of 15 patients with Parkinson ’s disease before and one week after operation were measured. Results: Postoperative cerebrospinal fluid dopamine levels were not significantly different from those before surgery, while serotonin, norepinephrine and 5-hydroxyindole-acetic acid were significantly decreased. The tremor and myotonia of the contralateral and distal limbs were disappeared after the operation, however, Exercise can not improve symptoms. CONCLUSIONS: Multiple neurotransmitters in the central postoperative Parkinson’s disease have changed and are temporarily balanced at low levels. Neurotransmitter biochemical changes from the central nervous system, brain stereotactic surgery can not completely cure Parkinson’s disease