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目的观察原发性高血压(EH)患者服用赖诺普利治疗前后血清胰岛素样生长因子-I(IGF-I)的变化,探讨IGF-I在EH的发生发展过程中所起的可能作用。方法47例EH患者均行超声心动图检查,用放免法测定赖诺普利治疗前、治疗后半年及23例正常对照者血清IGF-I水平。结果EH患者血清IGF-I水平明显高于对照组分别为(22.23±10.06)ng/ml对(15.91±7.59)ng/ml,P<0.01。I~Ⅲ级间比较也有显著性差异(F=3.53,P<0.05),Ⅲ级(28.61±13.10)ng/ml高于Ⅱ级(22.64±9.94)ng/ml,Ⅱ级高于I级(18.09±6.11)ng/ml。EH伴左心室肥厚(LVH)者高于无LVH者(25.95±11.20)ng/ml对(18.68±7.43)ng/ml,P<0.05。IGF-I与左心室重量指数中度相关(r=0.54)。赖诺普利治疗6个月后,血清IGF-I水平由(22.23±10.06)ng/ml降至(16.82±7.93)ng/ml,P<0.05。结论EHLVH患者IGF-I水平升高,赖诺普利治疗后IGF-I水平下降,IGF-I可能参与EHLVH的形成。
Objective To observe the changes of serum insulin-like growth factor-I (IGF-I) in patients with essential hypertension (EH) before and after treatment with lisinopril, and to explore the possible role of IGF-I in the development and progression of EH. Methods Eighteen EH patients underwent echocardiography. Serum IGF-I levels were measured by radioimmunoassay before and after treatment with lisinopril for six months and 23 normal controls. Results Serum levels of IGF-I in EH patients were significantly higher than those in control group (22.23 ± 10.06) ng / ml vs (15.91 ± 7.59) ng / ml, respectively, P <0.01. There was also a significant difference between I and III (F = 3.53, P <0.05), grade Ⅲ (28.61 ± 13.10) ng / ml was higher than grade Ⅱ (22.64 ± 9.94) ng / ml, 18.09 ± 6.11) ng / ml. EH patients with left ventricular hypertrophy (LVH) were higher than those without LVH (25.95 ± 11.20) ng / ml vs (18.68 ± 7.43) ng / ml, P <0.05. IGF-I was moderately associated with left ventricular mass index (r = 0.54). Serum IGF-I level decreased from (22.23 ± 10.06) ng / ml to (16.82 ± 7.93) ng / ml, P <0.05 after 6 months of lisinopril treatment. Conclusion IGF-I levels are elevated in patients with EHLVH, IGF-I levels are decreased after lisinopril treatment, IGF-I may be involved in the formation of EHLVH.