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研苯硼酸衍生物有3种不同构象(syn,syn-;syn,anti-和anti,anti-构象),这3种构象能量非常不同.苯硼酸衍生物通常是采用能量最低的syn,anti-构象存在.然而在配合物中,苯硼酸衍生物展现了硼酸功能团的构象多样性.在本文中,我们采用syn,syn-构象的硼酸衍生物作为结构单元,与含氮给体化合物反应,合成了一系列共晶配合物.采用的含氮给体化合物包括含1,2-重氮片段的化合物(阿普唑仑,1H-四唑,乙酰唑胺和苯并三唑)、邻菲罗啉和2,2′-联吡啶.结果表明,只有1,2-重氮片段不一定能与syn,syn-构象的硼酸及衍生物生成共晶.
There are three different conformations (syn, syn-; syn-, anti-and anti-anti conformation) of the phenylboronic acid derivatives, and the three conformers have very different energy.Phenylboronic acid derivatives are usually synthesized using the lowest energy syn- However, in the complex, benzene boronic acid derivatives exhibit the conformational diversity of boronic acid functional groups.In this paper, we use the syn, syn-conformational boronic acid derivatives as the structural unit, and react with the nitrogen-containing donor compounds, A series of eutectic complexes were synthesized using nitrogen-containing donor compounds including 1,2 diazotization fragments (alprazolam, 1H-tetrazole, acetazolamide and benzotriazole), phenanthrene The results showed that only the 1,2-diazotans could not form eutectic with the syn, syn-conformational boronic acids and their derivatives.