抗肿瘤化疗的成功与否,在很大程度上受到肿瘤抗药性的制约。谷胱甘肽硫转移酶(GSTs)是一组多功能酶,催化谷胱甘肽与各种电离化合物包括细胞毒性药物结合。在人类,主要有三类结构和功能不同的GSTs。有研究表明,谷胱甘肽硫转移酶π(GST-π)是耐药细胞系中主要的同工酶。作者用免 The success of anti-tumor chemotherapy is largely constrained by tumor resistance. Glutathione S-transferases (GSTs) are a group of multifunctional enzymes that catalyze the binding of glutathione to a variety of ionizing compounds, including cytotoxic drugs. In humans, there are mainly three types of GSTs with different structures and functions. Studies have shown that glutathione S-transferase π (GST-π) is the major isozyme in drug-resistant cell lines. Author use free