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以硼酸为催化剂,由芳香醛、β-酮酸酯和尿素合成了系列3,4-二氢嘧啶-2-酮衍生物。在无溶剂条件下回流反应1～2h,反应产率可达73%～92%。产物结构经1HNMR、IR确证。该方法具有催化剂廉价易得,反应时间短,收率高,对环境友好等优点。
With boric acid as catalyst, a series of 3,4-dihydropyrimidin-2-one derivatives were synthesized from aromatic aldehydes, β-ketoesters and urea. Under solvent-free conditions, the reaction was refluxed for 1 to 2 hours, and the yield of the reaction reached 73% to 92%. The product structure was confirmed by 1HNMR, IR. The method has the advantages of cheap and easy catalyst, short reaction time, high yield and environment friendliness.