妇产科手术结束前后硬膜外注射吗啡可获得良好镇痛效果.为预防不良反应,随机分为三组.预防Ⅰ组:吗啡2～3mg与甲氧氯普胺10mg、苯海拉明20mg混合后,注入硬膜外腔。预防Ⅱ组:硬膜外注入吗啡2～3mg后,肌注甲氧氯普胺10mg、苯海拉明20mg.对照组:硬膜外注入吗啡后,不用预防药.三组术后镇痛效果比较,P>0.05。预防吗啡不良反应:Ⅰ组显著优于Ⅱ组及对照组,P<0.01. Morphine injection of epidural analgesia before and after the end of obstetrics and gynecology surgery can get good analgesic effect.For the prevention of adverse reactions, were randomly divided into three groups.Prevention group: morphine 2 ~ 3mg and metoclopramide 10mg, diphenhydramine 20mg After mixing, inject into the epidural space. Prevention group Ⅱ: epidural morphine 2 ~ 3mg, intramuscular metoclopramide 10mg, diphenhydramine 20mg.Control group: after epidural morphine injection, no prophylaxis .Three groups of postoperative analgesia Comparison, P> 0.05. Prevention of morphine adverse reactions: Ⅰ group was significantly better than the Ⅱ group and the control group, P <0.01.