曾报道隔山消(Cynanchum wilfordi)的生物碱粗组分对醛氧化酶的活性以及脂质过氧化具有明显的抑制作用。本文介绍了从生物碱粗组分中分离出一种甾体生物碱gagaminine,并体外研究其对脂质过氧化和醛氧化酶的影响。结果:gagaminine明显抑制大鼠肝组织中脂质过氧化物的形成,抑制肝 It has been reported that the alkaloid fraction of Cynanchum wilfordi has a significant inhibitory effect on aldehyde oxidase activity and lipid peroxidation. This article describes the isolation of gagaminine, a steroidal alkaloid from crude alkaloid fractions, and its in vitro effects on lipid peroxidation and aldehyde oxidase. RESULTS: Gagaminine significantly inhibited the formation of lipid peroxides in rat liver tissue and inhibited the liver