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目的研究并对比美托洛尔以及卡维地洛在慢性充血性心力衰竭中的临床治疗效果。方法 84例慢性充血性心力衰竭患者,随机分成卡维地洛组和美托洛尔组,各42例。卡维地洛组给予卡维地洛口服治疗,美托洛尔组接受美托洛尔口服治疗。观察并比较两组患者在治疗前后的心功能以及左心室舒张末期内径(LVEDd)、左心室射血分数(LVEF)指标的改善情况。结果卡维地洛组的治疗总有效率为92.9%,美托洛尔组的治疗总有效率为76.2%,比较差异有统计学意义(χ~2=4.4594,P<0.05)。两组患者治疗后LVEDd、LVEF均比治疗前有明显改善,差异有统计学意义(P<0.05),而卡维地洛组LVEDd、LVEF改善情况显著优于美托洛尔组,差异有统计学意义(P<0.05)。结论采用两种药物治疗慢性充血性心力衰竭,均可有效地改善患者的心功能,对患者LVEDd、LVEF等指标的改善也有明显效果,而卡维地洛的治疗效果显著优于美托洛尔,更值得在慢性充血性心力衰竭的临床治疗中广泛应用。
Objective To study and compare the clinical effects of metoprolol and carvedilol in chronic congestive heart failure. Methods Eighty-four patients with chronic congestive heart failure were randomly divided into carvedilol group and metoprolol group, 42 cases in each group. Carvedilol group received oral carvedilol treatment, metoprolol group received metoprolol oral treatment. The changes of cardiac function, left ventricular end-diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) in both groups before and after treatment were observed and compared. Results The total effective rate was 92.9% in the carvedilol group and 76.2% in the metoprolol group. The difference was statistically significant (χ ~ 2 = 4.4594, P <0.05). LVEDd and LVEF after treatment in both groups were significantly improved than before treatment, the difference was statistically significant (P <0.05), while the carvedilol group LVEDd, LVEF improved significantly better than the metoprolol group, the difference was statistically Significance (P <0.05). Conclusion Both drugs can effectively improve the cardiac function in patients with chronic congestive heart failure, and also have a significant effect on the improvement of LVEDd and LVEF, while the effect of carvedilol is better than that of metoprolol , More worthy of being widely used in the clinical treatment of chronic congestive heart failure.