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目的:观察薏苡仁汤联合西药治疗类风湿关节炎的临床疗效和不良反应。方法:将82例类风湿关节炎患者随机分为对照组和治疗组各41例,分别应用单纯西药及在西药基础上加服薏苡仁汤,观察两组患者治疗前后晨僵时间、关节压痛数、关节肿胀数、类风湿因子、血沉、C-反应蛋白、血红蛋白和血管内皮生长因子水平;并对治疗3疗程后的两组患者行基本概念视觉模拟评分和关节疾病活动度评分;比较两组患者临床疗效。结果:两组患者治疗前后,晨僵时间、关节压痛数、关节肿胀数、类风湿因子、血沉、C-反应蛋白、血红蛋白水平及基本概念视觉模拟评分结果经比较,差异均有统计学意义(P<0.05);治疗组晨僵时间、关节压痛数、关节肿胀数、血沉、C-反应蛋白、血红蛋白和血管内皮生长因子水平治疗效果明显优于对照组(P<0.05),两组治疗后类风湿因子差异无统计学意义(P>0.05);治疗组基本概念视觉模拟评分和关节疾病活动度评分结果均明显高于对照组(P<0.05);但两组临床疗效经比较,差异无统计学意义(P>0.05)。结论:薏苡仁汤联合甲氨蝶呤与沙利度胺治疗类风湿关节炎的临床疗效优于用甲氨蝶呤与沙利度胺。
Objective: To observe the clinical efficacy and side effects of Coix seed soup and western medicine in the treatment of rheumatoid arthritis. Methods: 82 patients with rheumatoid arthritis were randomly divided into control group and treatment group, 41 cases, respectively, with Western medicine alone and on the basis of Western medicine plus Yiyiren soup were observed before and after treatment of morning stiffness time, joint tenderness , Joint swelling, rheumatoid factor, erythrocyte sedimentation rate, C-reactive protein, hemoglobin and vascular endothelial growth factor levels; basic concept visual analogue scale and joint disease activity score of two groups after three courses of treatment were compared; Clinical efficacy of patients. Results: There were significant differences in morning stiffness time, joint tenderness, joint swelling, rheumatoid factor, erythrocyte sedimentation rate, C-reactive protein, hemoglobin and basic concept visual analogue scale scores before and after treatment P <0.05). The treatment effect of morning stiffness, joint tenderness, swollen joint count, erythrocyte sedimentation rate, C-reactive protein, hemoglobin and vascular endothelial growth factor in the treatment group were significantly better than those in the control group Rheumatoid factor was no significant difference (P> 0.05); treatment group basic concept of visual analogue scale and joint disease activity score were significantly higher than the control group (P <0.05); but the clinical efficacy of the two groups by comparison, the difference was Statistical significance (P> 0.05). Conclusion: Coix seed soup combined with methotrexate and thalidomide treatment of rheumatoid arthritis clinical efficacy than methotrexate and thalidomide.