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目的观察拉贝洛尔联合硫酸镁治疗妊娠期高血压的临床疗效。方法收集2012年4月-2014年9月来医院就诊的妊娠期高血压患者212例,随机分为试验组和对照组各106例。试验组给予拉贝洛尔联合硫酸镁治疗,对照组仅给予硫酸镁,观察2组患者治疗前后血压变化及妊娠结局。结果 2组患者治疗前血压相近,差异无统计学意义(P>0.05)。治疗后2组患者收缩压及舒张压均有所降低,且试验组降低幅度均大于对照组,差异均有统计学意义(P<0.05)。试验组患者异常妊娠结局发生率为34.91%低于对照组的61.32%(P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠期高血压可显著降低患者血压和异常妊娠结局发生率,具有良好的治疗效果。
Objective To observe the clinical efficacy of labetalol and magnesium sulfate in the treatment of gestational hypertension. Methods A total of 212 hypertensive patients with gestational hypertension who visited the hospital from April 2012 to September 2014 were randomly divided into two groups: experimental group (106 cases) and control group (106 cases). The experimental group was given labetalol combined with magnesium sulfate, while the control group only given magnesium sulfate. The changes of blood pressure and pregnancy outcome were observed before and after treatment in two groups. Results The blood pressure of two groups before treatment was similar, with no significant difference (P> 0.05). After treatment, the systolic and diastolic blood pressure were decreased in both groups, and the reduction in the experimental group was greater than that in the control group, with significant differences (P <0.05). The incidence of abnormal pregnancy outcomes in trial group was 34.91%, lower than that in control group (61.32%, P <0.05). Conclusion The combination of labetalol and magnesium sulfate in the treatment of gestational hypertension can significantly reduce the incidence of abnormal blood pressure and abnormal pregnancy outcomes and has a good therapeutic effect.