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以抗CEA、EGF-γ和血型前体Y配基抗原的单抗进行分析,结果表明:结肠癌组织中表达CEA和血型前体Y配基较强,而EGF-γ表达水平极低;进一步鉴定分析,识别血型前体Y配基抗原决定簇的单抗C_(14)与肿瘤具有较好的反应性。并发现这种决定簇存在于各种生物大分子中,包括以糖蛋白和糖脂形式存在,并表达于EGF-γ与CEA分子中。这一结果提示血型前体抗原过量表达于肿瘤细胞中,不但是血型组织相容抗原,可能也参与到一些特殊生物分子中,应深入研究和鉴定其功能。
The anti-CEA, EGF-γ and blood group precursor Y ligand monoclonal antibody analysis showed that: colon cancer tissue expression of CEA and blood group precursor Y ligand stronger, and EGF-γ expression level is very low; further Identification and analysis, the monoclonal antibody C_ (14) that recognizes the blood group Y determinant has good reactivity with the tumor. And found that this determinant exists in a variety of biological macromolecules, including glycoproteins and glycolipids in the form, and expressed in EGF-gamma and CEA molecules. This result suggests that the type I precursor antigen is overexpressed in the tumor cells, not only the blood group compatible antigen, but also some special biomolecules, which should be further studied and identified.