自60年代以来,许多整体电生理实验结果表明,糖皮质激素能对下丘脑、中脑、海马和脊髓等部位的神经元电活动产生快速而且短暂的影响。这类反应的潜伏期只有数秒到数分钟,因此糖皮质激素不可能通过基因机制起作用,它可能还存在着其他的作用方式。目前已有生化实验的资料证实,两栖类和哺乳类某些细胞的质膜上存在糖皮质激素的膜结合位点。本室以往的研究结果亦提示在豚鼠腹腔神经 Since the 1960s, many overall electrophysiological experiments have shown that glucocorticoids have a rapid and transient effect on the electrical activity of neurons in the hypothalamus, midbrain, hippocampus and spinal cord. The latency of such reactions is only a matter of seconds to minutes, so glucocorticoids can not function through genetic mechanisms, and it may have other modes of action. Biochemical experiments have now confirmed the existence of some cells in amphibians and mammalian plasma membrane glucocorticoid membrane-binding sites. Our previous findings also suggest that in guinea pig celiac nerves