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脱乙酰壳多糖(CH)作为缓释制剂的骨架已有报道,但CH在片剂处方中用量少时不能达到缓释目的,只有在用量超过50％时可用作非浸蚀型骨架。另外,CH在低pH时能迅速成为凝胶,而在高pH时胶凝能力差。为此作者以呋喃苯胺酸为模型药物,研究了壳多糖苹果酸盐(CHM)缓释骨架片。缓释片采用直接压片法和湿颗粒法制备。药物释放采用USPⅩⅪ版浆法,释放介质为pH 7.4的磷酸缓冲液,样品干276.5 nm处分光光度法测定。实验比较了CH和CHM的缓释性质,研究了不同浓度的CHM(5％,
Chitosan (CH) has been reported as a sustained-release preparation. However, CH can not be used for sustained-release purposes when it is used in a small amount of tablets. It can be used as a non-erodible scaffold only when it is used in an amount of more than 50%. In addition, CH rapidly becomes a gel at low pH and poorly gels at high pH. Therefore, the author used furosemide as a model drug to study the chitosan malate (CHM) sustained release matrix tablets. Sustained release tablets using direct compression method and wet granulation method. Drug release using the USP XII version of the pulp method, the release medium was pH 7.4 phosphate buffer, the sample was measured at 276.5 nm spectrophotometry. The experiment compared the sustained-release properties of CH and CHM. The effects of different concentrations of CHM (5%