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目的:探讨IL-17基因rs2275913多态性与胃癌易感性的关系。方法:检索多个国内外数据库,收集有关IL-17基因G>A多态性位点rs2275913(G197A)与胃癌易感性的病例-对照研究。筛选文献、提取数据和文献质量评价后,采用STATA 12.1统计软件进行Meta分析。结果:最终纳入10个病例-对照研究,其中病例组4 371例,对照组5 345例。Meta分析结果显示,IL-17基因rs2275913位点多态性的等位基因模型(A vs.G)(OR=1.22,95%CI=1.10~1.37)与相加模型(AA vs.GG)(OR=1.58,95%CI=1.23~2.04)胃癌风险增加,显性模型(AG+GG vs.AA)(OR=0.63,95%CI=0.48~0.84)、隐性模型(GG vs.AG+AA)(OR=0.86,95%CI=0.78~0.94)胃癌风险降低(均P<0.05),但共显性模型(AG vs.AA+GG)(OR=0.91,95%CI=0.78~1.07)与罹患胃癌的风险无明显关系(P>0.05)。结论:IL-17基因rs2275913多态性的与胃癌易感性密切相关。
Objective: To investigate the relationship between rs2275913 polymorphism of IL-17 gene and gastric cancer susceptibility. Methods: We searched a number of domestic and foreign databases and collected case-control studies on the association of rs2275913 (G197A) IL-17 G> A polymorphism with gastric cancer susceptibility. After screening the literature, extracting the data and evaluating the quality of the literature, we conducted the meta-analysis using STATA 12.1 statistical software. RESULTS: Ten case-control studies were included, with 4,371 cases in the case group and 5,345 cases in the control group. Meta analysis showed that allele model (A vs. G) of rs2275913 polymorphism (OR = 1.22, 95% CI = 1.10-1.37) and additive model (AA vs. GG) OR = 1.58, 95% CI = 1.23 ~ 2.04) The risk of gastric cancer increased significantly (AG + GG vs. AA, OR = 0.63, 95% CI = 0.48-0.84) AA (OR = 0.86, 95% CI = 0.78-0.94)), but the co-dominant model (AG vs. AA + GG) ) Had no significant relationship with the risk of gastric cancer (P> 0.05). Conclusion: The rs2275913 polymorphism of IL-17 gene is closely related to the susceptibility to gastric cancer.