为评价新近心脏移植者左室舒张功能异常是否影响左室对后负荷急性增加时的反应,作者进行了研究。方法:22例新近心脏移植接受者在出院前进行了右心导管检查和心内膜活检。心肌活检无中或重度心脏排斥反应。病人临床情况稳定,左室射血分数(LVEF)正常,均接受免疫抑制治疗,其中仅1例用降压治疗,均未用α、β阻滞剂或钙拮抗剂治疗。首先获取基础血流动力学和静息时放射性核素血管造影或核素探测研究的结果,为检测心室对后负荷改变的反应,全部病人先静脉输注10μg/min硝酸苷油,逐渐增加剂量直至肺动脉楔压(PAWP)降低30%(平均30μg/min),此时重复血流动力学和放 To assess whether left ventricular diastolic dysfunction in recent heart transplant affects left ventricular response to an acute increase in afterload, the authors studied. METHODS: Twenty-two recent heart transplant recipients underwent right heart catheterization and endocardial biopsy prior to discharge. Myocardial biopsy in no or severe cardiac rejection. The patient was in stable clinical condition with normal left ventricular ejection fraction (LVEF) and received immunosuppressive therapy. Only 1 patient was treated with antihypertensive drugs, and none of them was treated with α, β blockers or calcium antagonists. First to obtain the results of basic hemodynamics and resting radionuclide angiography or radionuclide detection, in order to detect ventricular response to changes in postload, all patients with intravenous infusion of 10μg / min nitroglycerin oil, and gradually increase the dose Until pulmonary artery wedge pressure (PAWP) decreased 30% (average 30μg / min), then repeat the hemodynamic and release