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目的 探讨弱视的发病机制， 寻求一种客观评价幼儿视功能及预测弱视疗效的手段。方法 对正常组（６４ 只眼） 、弱视组（１２８ 只眼） 及治疗组（５９ 只眼） 行图形视觉诱发电位和视觉眼电图联合检测， 其结果用统计学方法分析。结果 弱视眼Ｐ１ 波较正常眼潜伏期延长、振幅降低， 弱视眼治疗后有效组视功能好转不仅表现在视力提高， 同时也客观反映在Ｐ１ 波潜伏期缩短、振幅增加； 弱视眼ＥＯＧ 峰电位和Ａｒｄｅｎ 比值均较正常眼偏低， 将分别记录的Ｐ－ ＶＥＰ 和Ｖ－ ＥＯＧ 进行相关分析，结果示Ｐ１ 波潜伏期与峰电位存在负相关。结论 说明弱视儿童视觉传导通道障碍， 视觉中枢存在发育和功能异常， 如不早期发现和矫治会发生形态学改变； 说明弱视治疗影响视觉中枢神经元功能及在人类的幼年视觉中枢有相当大的可塑性， 提示弱视早期发现和矫治的必要性， 临床视觉电生理是检测弱视儿童视功能的一种客观手段。
Objective To explore the pathogenesis of amblyopia and to seek a means to objectively evaluate the visual function of children and predict the effect of amblyopia. Methods The visual evoked potentials and visual electro-oculogram were detected in normal group (64 eyes), amblyopia group (128 eyes) and treatment group (59 eyes). The results were statistically analyzed. Results Compared with normal eyes, the P1 wave in amblyopic eyes prolonged and the amplitude decreased. The improvement of visual function in the effective group after amblyopia treatment reflected not only the improvement of visual acuity but also the shortening of P1 wave latency and amplitude. The EOG peak potentials and Arden ratios Were lower than the normal eye, P-VEP and V-EOG separately recorded correlation analysis showed that P1 wave latency and peak potential there is a negative correlation. Conclusions Amblyopia in children with visual conduction pathways, visual center existence and development of dysfunction, such as early detection and correction will not morphological changes; that amblyopia treatment of visual central neurons function and in human juvenile visual center considerable plasticity , Suggesting the necessity of early detection and correction of amblyopia. Clinical visual electrophysiology is an objective measure of visual function in amblyopia children.