ADRAC(澳大利亚药物不良反应顾问委员会)强调了P糖蛋白能导致药物相互作用的可能性。P糖蛋白能运转地高辛,但可被克拉霉素抑制。已有报道显示若治疗中同服地高辛和大环内酯类抗菌药时,地高辛血浓度会增加。 ADRAC收到2例患者因同服地高辛250μg·d~(-1)和罗红霉素治疗而引起地高辛中毒的不良反应报告。1例是一位76岁妇女在使用300mg·d~(-1)罗红霉素4天后,出现地高辛中毒的症状。第2例是一位80岁妇女在其包含地高辛的治疗方案中加入了罗 ADRAC (Australian Adverse Drug Reaction Advisory Board) highlights the possibility that P-glycoprotein can lead to drug interactions. P-glycoprotein works with digoxin but can be inhibited by clarithromycin. It has been reported that digoxin concentration increases when treated with digoxin and macrolide antibiotics. ADRAC received two patients with digoxin and 250μg · d ~ (-1) and roxithromycin treatment caused adverse reactions to digoxin poisoning. One patient, 76 years old, developed symptoms of digoxin poisoning after four days of 300 mg · d -1 roxithromycin. The second case was an 80-year-old woman who added Luo to her treatment program that contains digoxin