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目的 探讨血清层粘连蛋白 (LN)在慢性肾小疾病中的变化规律及其与肾功能的关系。方法 用放射免疫分析法测定了 2 1例健康人 (NC)组 ,34例慢性肾功能不全患者 (CRF)组 ,18例原发性肾小球疾病患者 (PGD)组以及 16例继发性肾小球疾病 (SGD)组的血清LN水平。结果 ( 1)慢性肾小球疾病患者 ,包括CRF、PGD、SGD组血清LN均显著高于NC组 (P <0 0 0 1) ;( 2 )PGD组血清LN低于SGD组 ,有显著性差异(P <0 0 0 1) ;( 3)CRF组血清LN高于PGD(P <0 0 0 1)。结论 血清LN水平可以反映肾小球损伤 ,似可作为PGD ,SGD的鉴别指标 ,并能反映肾小球疾病的进展趋势。
Objective To investigate the changes of serum laminin (LN) in chronic renal disease and its relationship with renal function. Methods Twenty-one healthy subjects (NC), 34 patients with chronic renal insufficiency (CRF), 18 patients with primary glomerular disease (PGD) and 16 patients with secondary Serum LN levels in glomerular disease (SGD) group. Results (1) Serum LN in patients with chronic glomerular disease, including CRF, PGD and SGD were significantly higher than those in NC (P <0.01). (2) Serum LN in PGD group was lower than that in SGD group (P <0.01). (3) Serum LN in CRF group was higher than that in PGD group (P <0.01). Conclusion The level of serum LN can reflect the glomerular injury, which can be used as a marker of PGD and SGD, and can reflect the progress of glomerular disease.