近年来呼吸生理和肺部疾病研究中的一个重大进展就是提出了小气道的概念,认为小气道病变可能是慢性阻塞性肺部疾病的早期可逆性阶段,如能早期发现及时处理,病变常是可逆的。为了早期发现小气道病变,国内外开展了以闭合气量(CV)、最大呼气流速一容量曲线(MMEF)等一系列小气道功能测定的研究。据报告这些 In recent years, a major advance in the research of respiratory physiology and lung diseases is to propose the concept of small airway. It is considered that small airway disease may be an early reversible stage of chronic obstructive pulmonary disease. If it can be found early and treated promptly, the lesion is often reversible. In order to detect small airway lesion at early stage, a series of small airway function tests, including closed volume (CV) and maximum expiratory flow rate-volume curve (MMEF), have been carried out at home and abroad. It is reported that these