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目的与方法 分析以肾损害为首发临床表现的20例狼疮性肾炎患者的临床与病理特点。结果 认为以肾损害为首发临床表现的狼疮性肾炎患者中男女性别比相对较高。病理类型以Ⅳ型为最常见。男性患者抗dsDNA阳性率与C3 下降者比例较女性高,病理活动性指数高,提示狼疮活动。结论 当患者无肾外多系统症状时,宜尽早行肾穿刺活检,予以早期确诊。早期强化免疫抑制治疗,效果较好。
Objective and Methods The clinical and pathological features of 20 cases of lupus nephritis with renal injury as the first clinical manifestation were analyzed. The results showed that kidney damage as the first clinical manifestations of lupus nephritis patients sex ratio is relatively high. Type Ⅳ is the most common pathological type. Male patients with anti-dsDNA positive rate of C3 decreased compared with women higher than the high activity index, suggesting lupus activity. Conclusion When patients without renal multiple system symptoms, renal biopsy should be performed as soon as possible, to be diagnosed early. Early strengthening of immunosuppressive therapy, the effect is better.