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目的 :探讨PEG 40 0 0浓缩尿中Ⅳ型胶原 (Ⅳ C)检测对诊断糖尿病肾病的作用。方法 :用ELISA法检测PEG 40 0 0浓缩尿中Ⅳ C浓度。结果 :健康对照组尿液Ⅳ C含量为 ( 4 47± 1 72 )ng/ml;糖尿病正常白蛋白尿组尿液Ⅳ C含量为 ( 6 12± 3 0 2 )ng/ml;糖尿病微量白蛋白尿组为 ( 12 0 7± 4 43 )ng/ml;糖尿病大量白蛋白尿组为 ( 14 5 3± 9 12 )ng/ml;非糖尿病肾病组浓缩尿Ⅳ C含量为 ( 4 68± 2 0 1)ng/ml。糖尿病人随着尿白蛋白分泌率 (AER)增加 ,血清和尿中Ⅳ C浓度也逐渐增加。结论 :用PEG 40 0 0浓缩尿中Ⅳ C的效果显著 ,血清和尿中Ⅳ C检测在诊断糖尿病肾病方面是有效的指标 ,可作为糖尿病肾病 (DN )和非糖尿病肾病 (NDRD)的鉴别指标。
Objective: To investigate the effect of PEG 40 0 0 concentration urine on the diagnosis of diabetic nephropathy. Methods: The urine concentration of IV C in PEG 40 0 0 was detected by ELISA. Results: Urine Ⅳ C content in healthy control group was (477 ± 1 72) ng / ml, urinary IV C content in normal albuminuria group was (6 12 ± 30 2) ng / ml, and diabetic microalbuminuria (12 0 7 ± 4 43) ng / ml in the urine group, (14 5 3 ± 9 12) ng / ml in the diabetic group with albuminuria, and 4 68 ± 20 in the non-diabetic nephropathy group 1) ng / ml. With the increase of urinary albumin excretion rate (AER) in diabetic patients, serum and urine IV C concentrations also gradually increased. Conclusion: The concentration of PEG 40 0 0 in the urine of patients with significant effect of Ⅳ C, serum and urine Ⅳ C detection in the diagnosis of diabetic nephropathy is an effective indicator of diabetic nephropathy (DN) and non-diabetic nephropathy (NDRD) indicators .