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目的探讨与卡托普利、咪达普利相关咳嗽的发生率及应对策略。方法采用随机、双盲方法,1～2级高血压患者符合入选标准者,分为卡托普利组和咪达普利组,分别给予卡托普利75～150mg,3次/d,口服,咪达普利2.5～10.0mg,1次/d,顿服,出现咳嗽症状者,加服拜阿司匹林0.3g,1次/d,观察治疗4周,比较二组咳嗽发生率及加服拜阿司匹林后咳嗽改善情况。结果卡托普利组咳嗽发生率20.92%,咪达普利组咳嗽发生率9.15%,二组比较咳嗽发生率差异有统计学意义(P<0.001)。咳嗽患者加服拜阿司匹林0.3g/d后,咳嗽明显减轻或消失者,卡托普利组48.28%,咪达普利组46.15%,二组有效率比较差异无统计学意义(P>0.05)。结论咪达普利相关咳嗽发生率明显低于卡托普利,ACEI相关咳嗽患者加服阿司匹林部分有效。
Objective To investigate the incidence of cough associated with captopril and imidapril and the corresponding strategies. Methods Patients were randomly divided into captopril group and imidapril group. Patients were given captopril 75 ~ 150mg, 3 times daily, orally , Imidapril 2.5 ~ 10.0mg, 1 / d, Dayton clothing, cough symptoms were added plus service aspirin 0.3g, 1 / d, observed for 4 weeks, the incidence of cough in both groups and plus service After aspirin cough to improve the situation. Results The incidence of cough in captopril group was 20.92%, the incidence of cough in imidapril group was 9.15%, and the incidence of cough in the two groups was statistically significant (P <0.001). Cough patients and after serving aspirin 0.3g / d, cough significantly reduced or disappeared, captopril 48.28%, Imidapril 46.15%, the two groups were no significant difference in the efficiency (P> 0.05) . Conclusions The incidence of pertussis-related cough was significantly lower than that of captopril, and some patients with ACEI-related cough were partially treated with aspirin.